化学化工学院
化学生物学系

樊春海
李富友
凌代舜
顾宏周
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樊春海,上海交通大学王宽诚讲席教授,中国科学院院士。

南京大学学士、博士,加州大学圣芭芭拉分校博士后。2004-2018年任中国科学院上海应用物理研究所研究员。

2018年起任上海交通大学化学化工学院教授,现任转化医学研究院执行院长、国家转化医学科学中心唐仲英首席科学家。

兼任美国化学会ACS Applied Materials & Interfaces副主编,Angewandte Chemie, Accounts of Chemical Research, ACS Nano等十余份国际知名杂志编委,ChemPlusChem编委会共同主席。

入选美国科学促进会(AAAS)、国际电化学学会(ISE)、美国医学和生物工程院(AIMBE)和英国皇家化学会(RSC)会士。

已发表论文500余篇,引用近5万次,H因子>110,近七年连续入选“全球高被引科学家”。
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李富友,教授,博士生导师

电子邮箱:fyli@fudan.edu.cn

办公地点:上海市杨浦区淞沪路2005号 复旦大学江湾校区化学楼 A5001室

电话:86-21-31244185   

主要从事发光材料及其生物应用研究,研究内容涉及:上转换发光材料(包括稀土纳米材料和小分子染料)和反应性发光探针(包括荧光染料和磷光铱配合物)用于生物成像;发光材料用于食品检测和疾病诊断

兼任Inorganic Chemistry、Nano Research、Contrast Media and Molecular Imaging和《化学学报》等期刊编委。


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凌代舜,上海交通大学变革性分子前沿科学中心/化学化工学院教授,博士生导师,国家“青年千人计划”入选者,国家优秀青年科学基金获得者,国家重点研发计划青年科学家项目首席,重大研究计划培育项目负责人, 上海市优秀学术带头人,浙江省特聘专家,钱江学者特聘教授,省高校高水平创新团队负责人,“一带一路”联合实验室主任,教育部重点实验室(生物医学工程)方向负责人。

主要从事纳米探针、化学生物学、活体成像分析和医学诊疗的研究,以生物体系活体成像分析和疾病精准诊疗为目标,在纳米探针设计、组装调控、多维度精准成像分析等方向取得了系列创新研究成果。

迄今,已发表SCI论文120篇,总引用超过8000次,ESI高被引论文8篇,以第一或通讯作者(含共同)在Nature Nanotechnol.、Nature Mater.、Nature Biomed. Eng.、Nature Commun.、J. Am. Chem. Soc.、Adv. Mater.、Angew. Chem. Int. Ed.、Nano Today、Adv. Funct. Mater.、ACS Cent. Sci.、ACS Nano、Nano Lett.等著名国际刊物上发表论文70余篇,应邀参编英文学术著作3部,授权国际和国内发明专利24项。

联系方式:

邮箱:dsling@sjtu.edu.cn

网站:www.dsling.cn

地址:上海市闵行区东川路800号转化医学研究院3楼E区   邮编:200240

国内外学术期刊兼职情况:

  • Exploration   副主编   2021-至今

  • Nano Select   副主编   2020-至今

  • Advanced Drug Delivery Reviews   专刊主编

  • Journal of Controlled Release   助理主编   2020-至今

  • The Innovation   学术编委   2020-至今

  • Science Bulletin   编委(工作委员会)   2018-至今

  • Chinese Chemical Letters   青年编委   2018-至今

  • Acta Pharmaceutica Sinica B   青年编委   2018-至今

  • Chemical Research in Chinese Universities   青年编委   2019-至今

  • Journal of Nanomaterials   杂志客座编辑

  • 生物加工过程   编委   2018-至今

  • 以及Nature Mater., J. Am. Chem. Soc., Adv. Mater., ACS Nano, Nano Lett., Biomaterials, Small, ACS Appl. Mater. Inter.等期刊审稿人

学术组织兼职情况

  • 中国生物物理学会材料生物学与智能诊疗技术分会   常务委员兼副会长   2019.07-至今

  • 中国生物材料学会影像材料与技术分会委员

  • 中国生物物理学会纳米生物学分会理事

  • 中国生物物理学会材料生物学与智能诊疗技术分会常务委员兼秘书长

  • 中国毒理学会纳米毒理专业委员会委员

  • 中国生物医学工程学会纳米医学专业青年委员会委员

  • 中国解剖学会血管分会委员

  • 中国抗癌协会纳米肿瘤学专业委员会第一届青年委员会委员

  • 第二届中国药学会《药学学报》中英两刊青年编委

  • 浙江省药学会药剂专业委员会委员兼副秘书长和青委会主任委员

  • 浙江省毒理学会纳米毒理专业委员会委员

荣誉与获奖:

  • 2021年获《Journal of Nanobiotechnology》评选的“2021 JNB Rising Star Awards”

  • 2019年获浙江大学药学院石华玉青年教师奖教金

  • 2018年获教育部科技进步奖一等奖(第三完成人)

  • 2018年获浙江省药学会科学技术奖二等奖(第一完成人)

  • 2018年获中国药学大会优秀论文三等奖

  • 2015年获中国生物材料大会评选的“青年杰出学者奖”

  • 2015年获中国药学会评选的“青年药剂学奖”

  • 2014年获韩国生物情报中心(BRIC)评选的“学术新星”

  • 2013年获国家留学基金委“国家优秀自费留学生奖学金”

  • 2012年获美国化学会和国际纳米毒理学会“杰出青年学者奖”

  • 中组部“青年千人计划”

学术主页:


代表性学术成果:

  1. Jianan Liu#, Fangyuan Li#, Yi Wang#, Limin Pan#, Peihua Lin, Bo Zhang, Yanrong Zheng, Yingwei Xu, Hongwei Liao, Giho Ko, Fan Fei, Cenglin Xu, Yang Du, Kwangsoo Shin, Dokyoon Kim, Sung-Soo Jang, Hee Jung Chung, He Tian, Qi Wang, Wei Guo, Jwa-Min Nam, Zhong Chen*, Taeghwan Hyeon*, Daishun Ling*, A Sensitive and Specific Nanosensor for Monitoring Extracellular Potassium Levels in the Brain, Nature Nanotechnology, 2020, 15, 321-330.

  2. Zeyu Liang#, Qiyue Wang#, Hongwei Liao#, Meng Zhao, Jiyoung Lee, Chuang Yang, Fangyuan Li, Daishun Ling*, Artificially engineered antiferromagnetic nanoprobes for ultra-sensitive histopathological level magnetic resonance imaging, Nature Communications, 2021, in press.

  3. Qinjie Weng#, Heng Sun#, Chunyan Fang#, Fan Xia, Hongwei Liao, Jiyoung Lee, Jincheng Wang, An Xie,Jiafeng Ren, Xia Guo, Fangyuan Li, Bo Yang, Daishun Ling*. Catalytic activity tunable ceria nanoparticles prevent chemotherapy-induced acute kidney injury without interference with chemotherapeutics, Nature Communications, 2021, 12, 1436.

  4. YangLu#, Yunjun Xu#, Guobing Zhang#, Daishun Ling#, Mingquan Wang, Yong Zhou, YaDong Wu, Tao Wu, Michael J. Hackett, Byung Hyo Kim, Hogeun Chang, Jonghoon Kim, Xintian Hu, Liang Dong, Nohyun Lee, Fangyuan Li, Jiacai He, Li Zhang, Huiqin Wen, Bo Yang, Seung Hong Choi*, Taeghwan Hyeon*,Duohong Zou*, Iron Oxide Nanoclusters for T1 Magnetic Resonance Imaging of Non-Human Primates, Nature Biomedical Engineering, 2017, 1(8), 637-643.

  5. Peihua Lin#, Mengda Cao#, Fan Xia, Hongwei Liao, Heng Sun, Qiyue Wang, Jiyoung Lee, Yan Zhou, Yunan Guan, Cheng Zhang, Zhiqiang Xu, Fangyuan Li*, Ji-Fu Wei*, Daishun Ling*. A Phosphatase-Mimetic Nano-Stabilizer of Mast Cells for Long-Term Prevention of Allergic Disease, Advanced Science, 2021, 8(5), 2004115.

  6. Heng Sun#, Yan Zhong#, Xiandi Zhu#, Hongwei Liao#, Jiyoung Lee, Ying Chen, Lijuan Ma, Jiafeng Ren, Meng Zhao, Mengjiao Tu, Fangyuan Li, Hong Zhang, Mei Tian*, Daishun Ling*. A Tauopathy-Homing and Autophagy-Activating Nanoassembly for Specific Clearance of Pathogenic Tau in Alzheimer's Disease. ACS Nano, 2021,15(3), 5263-5275.

  7. Xi Hu#, Fangyuan Li#, Fan Xia#, Xia Guo, Nan Wang, Lili Liang, Bo Yang, Kelong Fan, Xiyun Yan, Daishun Ling*, Biodegradation-Mediated Enzymatic Activity-Tunable Molybdenum Oxide Nanourchins for Tumor-Specific Cascade Catalytic Therapy, Journal of the American Chemical Society, 2020, 142(3), 1636-1644.

  8. Jin Wang#, Yinhang Jia#, Qiyue Wang#, Zeyu Liang#, Guangxu Han, Zejun Wang, Jiyoung Lee, Meng Zhao, Fangyuan Li, Ruiliang Bai*, Daishun Ling*, An Ultra-High Field-Tailored T1-T2 Dual-Mode MRI Contrast Agent for High-Performance Vascular Imaging, Advanced Materials, 2020, 33(2), 2004917.

  9. Fangyuan Li#, Yueping Qiu#, Fan Xia#, Heng Sun, Hongwei Liao, An Xie, Jiyoung Lee, Peihua Lin, Min Wei, Yanfei Shao, Bo Yang, Qinjie Weng*, Daishun Ling*, Dual Detoxification and Inflammatory Regulation by Ceria Nanozymes for Drug-Induced Liver Injury Therapy, Nano Today, 2020, 35, 100925.

  10. Xi Hu#, Fan Xia, Jiyoung Lee, Fangyuan Li, Xiaoyang Lu, Xiaozhen Zhuo, Guangjun Nie*, Daishun Ling*, Tailor-Made Nanomaterials for Diagnosis and Therapy of Pancreatic Ductal Adenocarcinoma, Advanced Science, 2021, 8(7), 2002545.

  11. Qiyue Wang#, Xibo Ma#, Hongwei Liao#, Zeyu Liang, Fangyuan Li*, Jie Tian*, Daishun Ling*, Artificially Engineered Cubic Iron Oxide Nanoparticle as a High-Performance Magnetic Particle Imaging Tracer for Stem Cell Tracking, ACS Nano, 2020,14(2), 2053-2062.

  12. Meng Zhao#, Zeyu Liang#, Bo Zhang#, Qiyue Wang#, Jiyoung Lee, Fangyuan Li, Qi Wang, Da Ma, Daishun Ling*, A Supramolecular Container-Mediated Surface Engineering Approach for Regulating the Biological Targeting Effect of Nanoparticles, Nano Letters, 2020, 20(11), 7941-7947.

  13. Tianyuan Zhang#, Fangyuan Li#, Qianhao Xu#, Qiyue Wang#,Xinchi Jiang#, Zeyu Liang, Hongwei Liao, Xianglei Kong, Jianan Liu, Honghui Wu, Danping Zhang, Changhua An, Liang Dong, Yang Lu, Hongcui Cao, Dokyoon Kim, Jihong Sun, Taeghwan Hyeon, Jianqing Gao*, Daishun Ling*, Ferrimagnetic Nanochains-Based Mesenchymal Stem Cell Engineering for Highly Efficient Post-Stroke Recovery, Advanced Functional Materials, 2019, 29(24), 1900603.

  14. Qinjie Weng#, Xi Hu#, Jiahuan Zheng#, Fan Xia#, Nan Wang, Hongwei Liao, Ying Liu, Dokyoon Kim, Jianan Liu, Fangyuan Li, Qiaojun He, Bo Yang, Chunying Chen, Taeghwan Hyeon, Daishun Ling*, Toxicological Risk Assessments of Iron Oxide Nanocluster- and Gadolinium-Based T1 MRI Contrast Agents in Renal Failure Rats, ACS Nano, 2019, 13(6), 6801-6812.

  15. Haibin Wu#, Fangyuan Li#, Wei Shao, Jianqing Gao*, Daishun Ling*, Promoting Angiogenesis in Oxidative Diabetic Wound Microenvironment Using a Nanozyme-Reinforced Self-Protecting Hydrogel, ACS Central Science, 2019, 5(3), 477-485.

  16. Jiahe Wu#, Fangyuan Li#, Xi Hu, Jingxiong Lu, Xiaolian Sun, Jianqing Gao*, Daishun Ling*, Responsive Assembly of Silver Nanoclusters with a Biofilm Locally Amplified Bactericidal Effect to Enhance Treatments against Multi-Drug-Resistant Bacterial Infections, ACS Central Science, 2019, 5(8), 1366-1376.

  17. Fangyuan Li#, Zeyu Liang#, Jianan Liu#, Jihong Sun, Xi Hu, Meng Zhao, Jiaxin Liu, Ruiliang Bai, Dokyoon Kim, Xiaolian Sun, Taeghwan Hyeon, Daishun Ling*, Dynamically Reversible Iron Oxide Nanoparticle Assemblies for Targeted Amplification of T1-Weighted Magnetic Resonance Imaging of Tumors, Nano Letters, 2019, 19(7), 4213-4220.

  18. Jingxiong Lu, Jihong Sun, Fangyuan Li, Jin Wang, Jianan Liu, Dokyoon Kim, Chunhai Fan, Taeghwan Hyeon, Daishun Ling*Highly Sensitive Diagnosis of Small Hepatocellular Carcinoma Using pH-Responsive Iron Oxide Nanocluster AssembliesJournal of the American Chemical Society, 2018, 140 (32), 10071–10074.

  19. Fangyuan Li#, Yang Du#, Jianan Liu#, Heng Sun, Jin Wang, Ruiqing Li, Dokyoon Kim, Taeghwan Hyeon, Daishun Ling*, Responsive Assembly of Upconversion Nanoparticles for pH-Activated and Near-Infrared-Triggered Photodynamic Therapyof Deep Tumors, Advanced Materials, 2018, 30(35), 1802808.

  20. Xi Hu#, Jihong Sun#, Fangyuan Li#, Ruiqing Li, Jiahe Wu, Jie He, Nan Wang, Jianan Liu, Shuaifei Wang, Fei Zhou, Xiaolian Sun, Dokyoon Kim, Taeghwan Hyeon, Daishun Ling*, Renal-Clearable Hollow Bismuth Subcarbonate Nanotubes for Tumor Targeted Computed Tomography Imaging and Chemoradiotherapy, Nano Letters, 2018, 18, 1196-1204.

  21. Fangyuan Li, Jingxiong Lu, Xueqian Kong, Taeghwan Hyeon, Daishun Ling*, Dynamic Nanoparticle Assemblies for Biomedical Applications, Advanced Materials, 2017, 29(14), 1605897.

本页面更新于:2021年6月10日


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顾宏周

博士,研究员,博士生导师
地址: 东安路130号,西13楼421室,上海 200032
电话: 021-54237322
邮件:
hongzhou.gu@fudan.edu.cn


工作经历

2015.6~今:复旦大学生物医学研究院,研究员
2009.11~2015.5:耶鲁大学分子生物系,博士后





教育经历

2004.8~2009.9:纽约大学,化学系,博士
1999.9~2004.7:中国科学技术大学,应用化学系,学士


研究方向

课题组致力于DNA纳米技术和核酸类分子探针的研究。我们过去以合成DNA为单元构建并组装精密可控的“纳米装配线”,将宏观法则移植应用于微观,提升纳米制备的手段;围绕适配体构建变构型分子传感器,实现了对目标分子的快速精确检测,并证明了其在高通量筛选新型抗生素药物方面的潜力;开发高效的试管内进化策略,筛选并发现具极强水解活性的DNA序列,揭示了DNA鲜为人知的一面。我们目前一方面在探索DNA纳米结构设计的新方法,另一方面在组装筛选可检测重大疾病信号分子的核酸探针,希望通过这些研究为DNA纳米生物工程学与转化医学间搭起一座桥梁。


代表论文

  1. Yang, Y., Wu, Z., Wang, L., Zhou, K., Xia, K., Xiong, Q., Liu, L., Zhang, Z., Chapman, E. R., Xiong, Y., Melia, T. J., Karatekin, E., Gu, H.*, and Lin, C.* (2021) Sorting sub-150-nm liposomes of distinct sizes by DNA-brick-assisted centrifugation. Nature Chemistry    https://www.nature.com/articles/s41557-021-00667-5*为通讯作者

  2. Jia Y, Chen L, Liu J, Li W, Gu H.* (2021) DNA-catalyzed efficient production of single-stranded DNA nanostructures. Chem https://www.cell.com/chem/fulltext/S2451-9294(20)30633-1*为通讯作者

  3. Zhang, C., Li, Q., Xu, T., Li, W., He, Y., and Gu H.* (2021) New DNA-hydrolyzing DNAs isolated from an ssDNA library carrying a terminal hybridization stem. Nucleic Acids Research *为通讯作者

  4. Du, X., Cheng, X., Li, W., Ge, Z., Zhong, C., Fan, C., and Gu, H.* (2021) Engineering Allosteric Ribozymes to Detect Thiamine Pyrophosphate in Whole Blood. Analytical Chemistry https://pubs.acs.org/doi/10.1021/acs.analchem.0c05276(*为通讯作者)

  5. Li, H.-Y., Yin, F.-F., Li, X.-Y., Jia, W.-N., Ding, J., Zhang, L., Wang, Z.-H., Hu, Q.-Q., Zuo, J.-L., Jia, H.-L., Wang, L.-H., Fan, C.-H.*, Gu, H.*, and Wu, J.* (2021) Novel aptasensor-based assay of sonic hedgehog ligand for detection of portal vein invasion of hepatocellular carcinoma. Biosensors & Bioelectronics 174 https://doi.org/10.1016/j.bios.2020.112738*为通讯作者)

  6. Tang, D.-J., Du, X., Shi, Q., Zhang, J.-L., He, Y.-P., Chen, Y.-M., Ming, Z., Wang, D., Zhong, W.-Y., Liang, Y.-W., Liu, J.-Y., Huang, J.-M., Zhong, Y.-S., An, S.-Q., Gu, H.*, and Tang, J.-L.* (2020) A SAM-I riboswitch with the ability to sense and respond to uncharged initiator tRNA. Nature Communications 11, 2794*为通讯作者)

  7. Li, Q., Zhang, S., Li, W., Ge, Z., Fan, C., & Gu, H.* (2020). Programming CircLigase Catalysis for DNA Rings and Topologies. Analytical Chemistry.*为通讯作者)

  8. Xia K, Shen J, Li Q, Fan C*, Gu H*. Near-Atomic Fabrication with Nucleic Acids. ACS Nano. 2020 Feb 25;14(2):1319-1337.*为通讯作者)

  9. Qinqin Hu; Hua Li; Lihua Wang; Hongzhou Gu*; Chunhai Fan*. “DNA Nanotechnology Enabled Drug Delivery systems.” Chemical Reviews 2018, doi: 10.1021/acs.chemrev.7b00663. *为通讯作者)

  10. Qinqin Hu; Sheng Wang; Lihua Wang; Hongzhou Gu*; Chunhai Fan*. “DNA Nanostructure-Based Systems for Intelligent Delivery of Therapeutic Oligonucleotides.” Advanced Healthcare Materials 2018, doi: 10.1002/adhm.201701153.*为通讯作者)

  11. Hongzhou Gu*. “Single-molecule Genotyping with Nanoscale DNA Shape IDs.” Science China Chemistry 2017, 60, doi: 10.1007/s11426-017-9073-6.*为通讯作者)

  12. Hongzhou Gu; Kazuhiro Furukawa; Zasha Weinberg; Daniel F. Berenson; Ronald R. Breaker. “Small, Highly-active DNAs that Hydrolyze DNA.” Journal of the American Chemical Society 2013, 135, 9121-9129.

  13. Hongzhou Gu; Ronald R. Breaker. “Production of Single-stranded DNAs by Self-cleavage of Rolling-circle Amplification Products.” BioTechniques 2013, 54, 337-343.
    Highlighted as the cover story of
    BioTechniques June issue, 2013.

  14. Hongzhou Gu; Kazuhiro Furukawa; Ronald R. Breaker. “Engineered Allosteric Ribozymes that Sense the Bacterial Second Messenger c-di-GMP.” Analytical Chemistry 2012, 84, 4935-4941.

  15. Hongzhou Gu; Jie Chao; Shou-Jun Xiao; Nadrian C. Seeman. “A Proximity-Based Programmable DNA Nanoscale Assembly Line.” Nature 2010, 465, 202-205.
    Academic commentaries in
    Nature by Lloyd M. Smith: “Molecular robots on the move”.
    Highlighted in
    Nature Nanotechnology: “DNA nanomachines: On the right track”.
    Highlighted by the Editorial in
    Nature Nanotechnology: “Help from above”.
    Highlighted in
    Nature Methods: “Robotics on the nanoscale”.

  16. Hongzhou Gu; Wei Yang; Nadrian C. Seeman. “DNA Scissors Device Used to Measure MutS Binding to DNA Mis-Pairs.” Journal of the American Chemical Society 2010, 132, 4352-4357.

  17. Hongzhou Gu; Jie Chao; Shou-Jun Xiao; Nadrian C. Seeman. “Dynamic Patterning Programmed by DNA Tiles Captured on a DNA Origami Substrate.” Nature Nanotechnology 2009, 4, 245-248.
    Highlighted by the 2011 Focus in
    Nature Nanotechnology: “DNA nanotechnology”.